Solomon A. Berson, M.D.

Biography

Solomon A. Berson was born on 22 April 1918, in New York City, and was the eldest of three children. His father, an immigrant from Russia, studied chemical engineering before becoming a business owner. Throughout his early schooling, Berson played music and chess. In 1938 Berson completed his undergraduate studies at New York University (NYU), in New York City, and he tried to pursue a medical career. However, every medical school to which he applied rejected him, so he returned to NYU to complete a master’s degree in science, which he received in 1939. Berson then accepted a teaching fellowship at the NYU College of Dentistry, which he held until he was able to start attending the NYU School of Medicine in 1941. While pursuing his MD, Berson married Miriam Gittleson in 1942, with whom he would later have two daughters, Wendy and Debby.

Berson completed his medical degree in 1945 and spent the following year interning at Boston City Hospital, in Boston, Massachusetts, before serving in the military for two years. After his time in the US Army, Berson completed a two-year residency in internal medicine at the Bronx VA Hospital. He planned to join the staff at the VA hospital in Bedford, Massachusetts, but he also considered staying at the Bronx VA to work with Yalow, Assistant Chief of the Radioisotope Service in the Radiotherapy Department.

Solomon A. Berson helped develop the radioimmunoassay (RIA) technique in the US during the twentieth century. Berson made many scientific contributions while working with research partner Rosalyn Yalow at the Bronx Veterans Administration (VA) hospital, in New York City, New York. In the more than twenty years that Berson and Yalow collaborated, they refined the procedures for tracing diagnostic biological compounds using isotope labels. In the late 1950s they developed the RIA based on the ability to trace the competition between and ligands, or small molecules that bind to specific sites of other biomolecules, and proteins for the same molecular binding site, a process called competitive binding. Scientists widely used Berson and Yalow's RIA, as these methods permit the use of a minimal sample of blood for accurate measurements of biological molecules such as hormones that cause the production of antibodies. Berson and Yalow’s research has advanced the study of physiology, including that of the reproductive system, with particular applications to the diagnosis and treatment of infertility.

Throughout the 1960s Berson served on the US National Advisory Council. He received several honors, including the Eli Lilly Award of the American Diabetes Association in 1957 and the William S. Middleton Research Award in 1960. In 1968 Berson became professor and chairman of the Department of Medicine at the Mount Sinai School of Medicine, within the City University of New York, in New York City. Yalow claimed that Berson’s acceptance of that position was a great loss for the scientific community because he did less research than he had before. In April of 1972 Berson was elected to the US National Academy of Sciences. That same month, he died from a heart attack while attending a conference for the Federation of American Societies for Experimental Biology in Atlantic City, New Jersey.

In remembrance of Berson’s contributions, Yalow requested that the Radioisotope Service laboratory be renamed the Solomon A. Berson Research Laboratory. In 1977 Yalow received the Nobel Prize in Physiology or Medicine for the co-discovery RIA. Though Yalow honored Berson for his involvement in that discovery, the Nobel Committee does not award posthumous prizes.

Craer, Jennifer R., "Solomon A. Berson (1918-1972)". Embryo Project Encyclopedia (2013-11-01). ISSN: 1940-5030 http://embryo.asu.edu/handle/10776/6471.